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Article

P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma

27 Mar 2013

Abstract excerpt

BACKGROUND: Although remarkable clinical response rates in melanoma have been observed using vemurafenib or dabrafenib in patients with tumors carrying oncogenic mutations in BRAF, a substantial unmet medical need remains for the subset of patients with wild-type BRAF tumors. METHODS: To investigate the role of p21-activated kinases (PAKs) in melanoma, we determined PAK1 genomic copy number and protein expression...

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Share to Cutaneous Melanoma Detection and Management
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Share to Protein Kinase Regulation and GTPase Signaling

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PMID: 23535073
DOI: 10.1093/jnci/djt054

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