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Article

The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.

Cancer research - 1 Nov 2009

Riesco-Eizaguirre Garcilaso, Rodríguez Irene, De la Vieja Antonio, Costamagna Eugenia, Carrasco Nancy, Nistal Manuel, Santisteban Pilar

Abstract excerpt

The activating mutation BRAF(V600E) is a frequent genetic event in papillary thyroid carcinomas (PTC) that predicts a poor prognosis, leading to loss of sodium/iodide symporter (NIS) expression and subsequent radioiodide-refractory metastatic disease. The molecular basis of such an aggressive behavior induced by BRAF remains unclear. Here, we show a mechanism through which BRAF induces NIS repression and promotes...

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Source

Identifiers

PMID: 19861538
DOI: 10.1158/0008-5472.CAN-09-1248

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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