Article
Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2015
Delpech Jean-Christophe, Madore Charlotte, Joffre Corinne, Aubert Agnès, Kang Jing Xuan, Nadjar Agnès, Layé Sophie
Abstract excerpt
Polyunsaturated fatty acids (PUFAs) display immunomodulatory properties in the brain, n-3 PUFAs being able to reduce inflammation whereas n-6 PUFAs are more pro-inflammatory. It has been extensively demonstrated that exposure to a peripheral immune challenge leads to the production and release of inflammatory mediators in the brain in association with cognitive deficits. The question arises whether n-3 PUFA...
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