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Article

Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.

The Journal of biological chemistry - 7 Nov 2014

Donninger Howard, Clark Jennifer A, Monaghan Megan K, Schmidt M Lee, Vos Michele, Clark Geoffrey J

Abstract excerpt

The Ras association domain family protein 1A (RASSF1A) is arguably one of the most frequently inactivated tumor suppressors in human cancer. RASSF1A modulates apoptosis via the Hippo and Bax pathways but also modulates the cell cycle. In part, cell cycle regulation appears to be dependent upon the ability of RASSF1A to complex with microtubules and regulate their dynamics. Which property of RASSF1A, apoptosis...

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Identifiers

PMID: 25225292
DOI: 10.1074/jbc.M114.609537
PMCID: PMC4223329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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