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Article

A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability.

Cancer research - 15 Jun 2004

Vos Michele D, Martinez Alfredo, Elam Candice, Dallol Ashraf, Taylor Barbara J, Latif Farida, Clark Geoffrey J

Abstract excerpt

The high frequency with which the novel tumor suppressor RASSF1A is inactivated by promoter methylation suggests that it plays a key role in the development of many primary human tumors. Yet the mechanism of RASSF1A action remains unknown. We now show that RASSF1A associates with microtubules and that this association is essential for RASSF1A to mediate its growth inhibitory effects. Overexpression of RASSF1A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15205337
DOI: 10.1158/0008-5472.CAN-04-0339

Genes

RASSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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