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CD147-CAR-NK cell therapy shows minimal toxicities in human CD147 transgenic mouse model with solid tumors

26 Feb 2025

Abstract excerpt

The toxicity of chimeric antigen receptor-natural killer (CAR-NK) therapy has not been tested in solid tumors, compared with CAR-T therapy side by side. To address this, we investigated the CD147-CAR-NK "on-target/off-tumor" toxicity and neurotoxicity in human CD147-transgenic (hCD147TG) mice with hepatocellular carcinoma (HCC). We first tested the in vitro cytotoxicity of CD147-CAR-NK against CD147 + tumor and...

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PMID: 40160933
DOI: 10.1016/j.omton.2025.200957

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