Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.

Abstract excerpt

A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups. These nocebo effects also play a major role in drug discontinuation in clinical practice, negatively affecting treatment efficacy as well as patient adherence and compliance. Experimental and clinical data...

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