Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is it personality or genes? - A secondary analysis on a randomized controlled trial investigating responsiveness to placebo analgesia.

Scandinavian journal of pain - 1 Jan 2025

van Lennep Johan P A, van Middendorp Henriët, Leong Oyin V, Kloet Susan L, Vossen Rolf H A M, Heyman Tom, Evers Andrea W M

Abstract excerpt

OBJECTIVES: To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of different personality characteristics and different single-nucleotide polymorphisms (SNPs) on the responsiveness to placebo analgesia. METHODS: Secondary data analyses were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to COMT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FAAH gene

Share to Personality

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Share to Young Adult

Source

Identifiers

PMID: 41135508
DOI: 10.1515/sjpain-2025-0029

Genes

COMT
FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is it personality or genes? - A secondary analysis on a randomized controlled trial investigating responsiveness to placebo analgesia.PMID 41135508Read ↗

Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures.Semantic proximity Read ↗

Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.Semantic proximity Read ↗

The opioid receptor mu 1 (OPRM1) rs1799971 and catechol-O-methyltransferase (COMT) rs4680 as genetic markers for placebo analgesia.Semantic proximity Read ↗

Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides.Semantic proximity Read ↗

Digital Phenotyping of Pain Modulation and Associations Among Personality, Attachment, and Behavioral Signatures: Cross-Sectional Study.Semantic proximity Read ↗

Psychophysiological responses to pain identify reproducible human clusters.Semantic proximity Read ↗

Five-factor personality traits and pain sensitivity: a twin study.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.Semantic proximity Read ↗

Sex moderates the association between the COMT Val158Met single-nucleotide polymorphism and disorderliness facet of novelty seeking.Semantic proximity Read ↗

Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients.Semantic proximity Read ↗

The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3'-untranslated region of the serotonin transporter gene (SLC6A4).Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.