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Article

Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans.

Fungal genetics and biology : FG & B - 1 Oct 2014

Jia Chang, Yu Qilin, Xu Ning, Zhang Bing, Dong Yijie, Ding Xiaohui, Chen Yulu, Zhang Biao, Xing Laijun, Li Mingchun

Abstract excerpt

The vacuolar-type H(+)-ATPase (V-ATPase) is a multiprotein complex consisting of the V0 and V1 sectors, and is required for vacuolar acidification and virulence in the opportunistic fungal pathogen Candida albicans. In this study, we identified C. albicans Tfp1 as a putative subunit of V-ATPase, and explored its importance in multiple cellular processes. Our results revealed that Tfp1 played an essential role in...

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PMID: 25220074
DOI: 10.1016/j.fgb.2014.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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