Article
Tfp1 is required for ion homeostasis, fluconazole resistance and N-Acetylglucosamine utilization in Candida albicans.
Biochimica et biophysica acta - 1 Oct 2015
Jia Chang, Zhang Kai, Yu Qilin, Zhang Bing, Xiao Chenpeng, Dong Yijie, Chen Yulu, Zhang Biao, Xing Laijun, Li Mingchun
Abstract excerpt
The vacuolar-type H+-ATPase (V-ATPase) is crucial for the maintenance of ion homeostasis. Dysregulation of ion homeostasis affects various aspects of cellular processes. However, the importance of V-ATPase in Candida albicans is not totally clear. In this study, we demonstrated the essential roles of V-ATPase through Tfp1, a putative V-ATPase subunit. Deletion of TFP1 led to generation of an iron starvation...
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