The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence.

doi:10.1099/mic.0.27505-0

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Article

The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence.

Microbiology (Reading, England) - 1 May 2005

Poltermann Sophia, Nguyen Monika, Günther Juliane, Wendland Jürgen, Härtl Albert, Künkel Waldemar, Zipfel Peter F, Eck Raimund

Abstract excerpt

The vacuolar H+-ATPase (V-ATPase) component Vma7p of the human-pathogenic yeast Candida albicans regulates hyphal growth induced by serum and Spider medium and is essential for virulence. In order to characterize the functions of the putative V-ATPase subunit Vma7p of C. albicans, null mutants were generated. The resulting mutants showed reduced vacuole acidification, which correlated with defective growth at...

Topics

Animals
Animals, Outbred Strains
Candida albicans
Candidiasis
Fungal Proteins
Gene Expression Regulation, Fungal
Humans
Hydrogen-Ion Concentration
Hyphae
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Protein Subunits

Vacuolar Proton-Translocating ATPases

Vacuoles

Virulence

Source

Open in PubMed

Identifiers

PMID: 15870472
DOI: 10.1099/mic.0.27505-0

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