Article
Full genotyping of a highly polymorphic human gene trait by time-resolved fluorescence resonance energy transfer.
PloS one - 1 Jan 2014
Totè Edoardo, Lamperti Marco, Bondani Maria, Salerno Domenico, Cassina Valeria, Nardo Luca
Abstract excerpt
The ability of detecting the subtle variations occurring, among different individuals, within specific DNA sequences encompassed in highly polymorphic genes discloses new applications in genomics and diagnostics. DQB1 is a gene of the HLA-II DQ locus of the Human Leukocyte Antigens (HLA) system. The polymorphisms of the trait of the DQB1 gene including codons 52-57 modulate the susceptibility to a number of...
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