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Article

MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD.

Blood - 16 Oct 2014

Stickel Natalie, Prinz Gabriele, Pfeifer Dietmar, Hasselblatt Peter, Schmitt-Graeff Annette, Follo Marie, Thimme Robert, Finke Jürgen, Duyster Justus, Salzer Ulrich, Zeiser Robert

Abstract excerpt

Acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT); therefore, a better understanding of its biology may improve therapeutic options. We observed miR-146a up-regulation in T cells of mice developing acute GVHD compared with untreated mice. Transplanting miR-146a(-/-) T cells caused increased GVHD severity, elevated tumor necrosis factor (TNF)...

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Share to Graft vs Host Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

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Share to TNF Receptor-Associated Factor 6

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Source

Identifiers

PMID: 25205119
DOI: 10.1182/blood-2014-04-569046

Genes

TNF
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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