Article
MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis.
The Journal of allergy and clinical immunology - 1 Feb 2017
Srivastava Ankit, Nikamo Pernilla, Lohcharoenkal Warangkana, Li Dongqing, Meisgen Florian, Xu Landén Ning, Ståhle Mona, Pivarcsi Andor, Sonkoly Enikö
Abstract excerpt
BACKGROUND: Psoriasis is an immune-mediated inflammatory skin disease with a strong genetic background in which activation of IL-17 signaling is central in the pathogenesis. Little has been known about the role of noncoding RNAs, including microRNAs (miRNAs), in predisposition to the disease. OBJECTIVE: We sought to investigate the genetic association of single nucleotide polymorphisms in microRNA-146a (miR-146a)...
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