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Article

MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors.

JCI insight - 26 Mar 2020

Marschner Dominik, Falk Martina, Javorniczky Nora Rebeka, Hanke-Müller Kathrin, Rawluk Justyna, Schmitt-Graeff Annette, Simonetta Federico, Haring Eileen, Dicks Severin, Ku Manching, Duquesne Sandra, Aumann Konrad, Rafei-Shamsabadi David, Meiss Frank, Marschner Patrick, Boerries Melanie, Negrin Robert S, Duyster Justus, Zeiser Robert, Köhler Natalie

Abstract excerpt

Immune checkpoint inhibitor (ICI) therapy has shown a significant benefit in the treatment of a variety of cancer entities. However, immune-related adverse events (irAEs) occur frequently and can lead to ICI treatment termination. MicroRNA-146a (miR-146a) has regulatory functions in immune cells. We observed that mice lacking miR-146a developed markedly more severe irAEs compared with WT mice in several irAE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32125286
DOI: 10.1172/jci.insight.132334
PMCID: PMC7213806

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