Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach.

Journal of biomolecular structure & dynamics - 1 Jan 2015

Jaiswal Amit, Lakshmi P T V

Abstract excerpt

Telomere holds special mechanism for solving end repair problems and maintaining genomic stability. Protection of telomeres 1 (POT1) which belongs to shelterin family is identified as a key protein that recruits telomerase by interacting with telomere repeat binding factors (TRB1-3). Since, deciphering the mechanism through which POT assembles telomerase is of great interest, computational approaches have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Hydrogen Bonding
Share to Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Quantitative Structure-Activity Relationship

Share to Telomerase

Share to Telomere

Share to Telomere-Binding Proteins

Source

Identifiers

PMID: 25204447
DOI: 10.1080/07391102.2014.953207

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach.PMID 25204447Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.Semantic proximity Read ↗

Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical AssaysSemantic proximity Read ↗

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric ProteinsSemantic proximity Read ↗

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer developmentSemantic proximity Read ↗

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNASemantic proximity Read ↗

Structure of active human telomerase with telomere shelterin protein TPP1Semantic proximity Read ↗

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeresSemantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.Semantic proximity Read ↗

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at TelomeresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.