Article
The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.
The Journal of biological chemistry - 6 Jul 2007
De Nicola Francesca, Bruno Tiziana, Iezzi Simona, Di Padova Monica, Floridi Aristide, Passananti Claudio, Del Sal Giannino, Fanciulli Maurizio
Abstract excerpt
We have previously demonstrated that DNA damage leads to stabilization and accumulation of Che-1, an RNA polymerase II-binding protein that plays an important role in transcriptional activation of p53 and in maintenance of the G(2)/M checkpoint. Here we show that Che-1 is down-regulated during the apoptotic process. We found that the E3 ligase HMD2 physically and functionally interacts with Che-1 and promotes its...
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