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Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.

Infection and immunity - 1 Mar 2018

Denham Steven T, Verma Surbhi, Reynolds Raymond C, Worne Colleen L, Daugherty Joshua M, Lane Thomas E, Brown Jessica C S

Abstract excerpt

Cryptococcus neoformans is a common environmental yeast and opportunistic pathogen responsible for 15% of AIDS-related deaths worldwide. Mortality primarily results from meningoencephalitis, which occurs when fungal cells disseminate to the brain from the initial pulmonary infection site. A key C. neoformans virulence trait is the polysaccharide capsule. Capsule shields C. neoformans from immune-mediated...

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Identifiers

PMID: 29203547
DOI: 10.1128/IAI.00662-17
PMCID: PMC5820953

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.PMID 29203547Read ↗

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