Article
Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
American journal of respiratory cell and molecular biology - 1 May 2015
Sharma Sunita, Kho Alvin T, Chhabra Divya, Qiu Weiliang, Gaedigk Roger, Vyhlidal Carrie A, Leeder J Steven, Barraza-Villarreal Albino, London Stephanie J, Gilliland Frank, Raby Benjamin A, Weiss Scott T, Tantisira Kelan G
Abstract excerpt
Antenatal corticosteroids enhance lung maturation. However, the importance of glucocorticoid genes on early lung development, asthma susceptibility, and treatment response remains unknown. We investigated whether glucocorticoid genes are important during lung development and their role in asthma susceptibility and treatment response. We identified genes that were differentially expressed by corticosteroids in two...
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