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Article

Lung Development Genes and Adult Lung Function.

American journal of respiratory and critical care medicine - 15 Sept 2020

Portas Laura, Pereira Miguel, Shaheen Seif O, Wyss Annah B, London Stephanie J, Burney Peter G J, Hind Matthew, Dean Charlotte H, Minelli Cosetta

Abstract excerpt

Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors.Objectives: To systematically investigate the effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested the association of 391 genes known to influence lung development with FVC and FEV1/FVC. We...

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Identifiers

PMID: 32392078
DOI: 10.1164/rccm.201912-2338OC
PMCID: PMC7491406

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