Article

Evolutionary Integration and Glucocorticoid Regulation of the Respiratory System: Structure, Function, and Homeostatic Adaptation.

2026-01-12

Abstract excerpt

The vertebrate respiratory system arose under evolutionary pressures that linked increasing atmospheric oxygen levels to the metabolic demands of mitochondria. This transition—from ancestral gill-based exchange to the highly alveolated mammalian lung—was accompanied by the emergence of a hormonal regulatory axis centered on the glucocorticoid receptor alpha (GRα). Over time, GRα became deeply integrated into the a...

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Literature Corpus work: 7ee3367f-62fd-5938-b84d-0b3ec3f228d8
DOI: 10.20944/preprints202601.0867.v1

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