Article

Mitochondrial Metabolic Reprogramming and NETs Dynamic Balance: Dual-axis Regulatory Mechanisms and Therapeutic Prospects for Acute Lung Injury Repair

2026-06-15

Abstract excerpt

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a spectrum of severe critical disorders with limited targeted treatments for core pathogenesis. Mitochondrial dysfunction and excessive neutrophil extracellular trap (NET) formation are well-recognized pivotal drivers of ALI pathogenesis. Aberrant mitochondrial metabolism induces robust reactive oxygen species (ROS) generation and mit...

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Literature Corpus work: f01ff61f-6ec5-5002-8d73-d87ed0db87e6
DOI: 10.22541/authorea.15004748/v1

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