Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding.

doi:10.1371/journal.pone.0106810

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Article

Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding.

PloS one - 1 Jan 2014

Kraus Christoph, Baldinger Pia, Rami-Mark Christina, Gryglewski Gregor, Gryglewsky Gregor, Kranz Georg S, Haeusler Daniela, Hahn Andreas, Wadsak Wolfgang, Mitterhauser Markus, Rujescu Dan, Kasper Siegfried, Lanzenberger Rupert

Abstract excerpt

BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-HTT) and the serotonin-1A (5-HT1A) receptor. Previous positron emission tomography (PET) studies on the association between Val66Met and 5-HTT and 5-HT1A binding potential (BPND) have demonstrated equivocal results....

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Identifiers

PMID: 25188405
DOI: 10.1371/journal.pone.0106810
PMCID: PMC4154779

Genes

HTT
BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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