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Article

Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.

Nucleic acids research - 1 Jun 2002

Rapić-Otrin Vesna, McLenigan Mary P, Bisi Dawn C, Gonzalez Martin, Levine Arthur S

Abstract excerpt

The UV-damaged DNA binding protein complex (UV-DDB) is implicated in global genomic nucleotide excision repair (NER) in mammalian cells. The complex consists of a heterodimer of p127 and p48. UV-DDB is defective in one complementation group (XP-E) of the heritable, skin cancer-prone disorder xeroderma pigmentosum. Upon UV irradiation of primate cells, UV-DDB associates tightly with chromatin, concomitant with the...

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Identifiers

PMID: 12034848
DOI: 10.1093/nar/30.11.2588
PMCID: PMC117178

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.PMID 12034848Read ↗

DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision RepairSemantic proximity Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.Semantic proximity Read ↗

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairSemantic proximity Read ↗

The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblastsSemantic proximity Read ↗

p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.Semantic proximity Read ↗

The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repairSemantic proximity Read ↗

The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription.Semantic proximity Read ↗

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.Semantic proximity Read ↗

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.Semantic proximity Read ↗

Prolonged stalling of RNA Polymerase II at DNA damage explains phenotypical differences between Cockayne and UV-sensitive syndromesSemantic proximity Read ↗

NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.Semantic proximity Read ↗

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