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Article

CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia.

Leukemia - 1 Mar 2015

Korthuis P M, Berger G, Bakker B, Rozenveld-Geugien M, Jaques J, de Haan G, Schuringa J J, Vellenga E, Schepers H

Abstract excerpt

As the transcriptional coactivator CITED2 (CBP/p300-interacting-transactivator-with-an ED-rich-tail 2) can be overexpressed in acute myeloid leukemia (AML) cells, we analyzed the consequences of high CITED2 expression in normal and AML cells. CITED2 overexpression in normal CD34(+) cells resulted in enhanced hematopoietic stem and progenitor cell (HSPC) output in vitro, as well as in better hematopoietic stem...

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Topics

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Share to Antigens, CD34
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to DNA Methyltransferase 3B

Share to Gene Expression Regulation, Leukemic

Share to Graft Survival

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 25184385
DOI: 10.1038/leu.2014.259

Genes

CITED2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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