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Article

The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity

5 Jun 2010

Abstract excerpt

The molecular basis for the unique proliferative and self-renewal properties that hierarchically distinguish human stem cells from progenitors and terminally differentiated cells remains largely unknown. We report a role for the Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) as an indispensable regulator of self-renewal in human stem cells and show that a functional dependence on Mcl-1 defines the human stem...

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PMID: 20525924
DOI: 10.1182/blood-2009-12-258095

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