Article
Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis.
Arthritis and rheumatism - 1 Mar 2006
Miyashita Risa, Tsuchiya Naoyuki, Yabe Toshio, Kobayashi Shigeto, Hashimoto Hiroshi, Ozaki Shoichi, Tokunaga Katsushi
Abstract excerpt
OBJECTIVE: Genetic background and infection have been implicated in the etiology of microscopic polyangiitis (MPA). Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of activating and inhibitory receptors expressed on natural killer (NK) cells and T cells, the genes of which show extreme polymorphism. Some KIRs bind to HLA class I subgroups, and genetic interactions between KIR genes and their...
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