Article
[Pharmacogenetic aspects of antiarrhythmic drug therapy].
Kardiologiia - 1 Jan 2014
Mironov N Iu, Nesterenko L Iu, Golitsyn S P
Abstract excerpt
It is known for a long time that individuals vary widely in their responses to therapy with different drugs. Variability in drug response may be due to variability in the relationship between drug dose and concentrations of the drug at target sites (pharmacokinetic variability). Another mechanism is that individuals vary in their response to identical exposures to a drug due to variability in the target molecule...
Topics
- Anti-Arrhythmia Agents
- Arrhythmias, Cardiac
- Biotransformation
- Dose-Response Relationship, Drug
- Drug Resistance
- Genetic Predisposition to Disease
- Humans
- Pharmacogenetics