Arrhythmia pharmacogenomics: methodological considerations.

Abstract excerpt

Abnormalities of cardiac rhythm are common clinical problems, resulting in symptoms such as palpitations, breathlessness, stroke, and sudden death. Drugs used to treat arrhythmias have variable actions ranging from completely effective to serious adverse effects, including (paradoxically) sudden death due to drug-induced arrhythmias. Experiments to define the genetic basis for arrhythmia susceptibility and...

Topics

• Animals
• Anti-Arrhythmia Agents
• Arrhythmias, Cardiac
• Death, Sudden, Cardiac
• Humans
• Pharmacogenetics
• Phenotype