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Article

Identifying rare and common disease associated variants in genomic data using Parkinson's disease as a model.

Journal of biomedical science - 30 Aug 2014

Lin Ying-Chao, Hsieh Ai-Ru, Hsiao Ching-Lin, Wu Shang-Jung, Wang Hui-Min, Lian Ie-Bin, Fann Cathy S J

Abstract excerpt

BACKGROUND: Genome-wide association studies have been successful in identifying common genetic variants for human diseases. However, much of the heritable variation associated with diseases such as Parkinson's disease remains unknown suggesting that many more risk loci are yet to be identified. Rare variants have become important in disease association studies for explaining missing heritability. Methods for...

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Identifiers

PMID: 25175702
DOI: 10.1186/s12929-014-0088-9
PMCID: PMC4428531

Genes

KREMEN1
HAS2
SNCA

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