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Article

The immune-related role of BRAF in melanoma.

Molecular oncology - 1 Jan 2015

Tomei Sara, Bedognetti Davide, De Giorgi Valeria, Sommariva Michele, Civini Sara, Reinboth Jennifer, Al Hashmi Muna, Ascierto Maria Libera, Liu Qiuzhen, Ayotte Ben D, Worschech Andrea, Uccellini Lorenzo, Ascierto Paolo A, Stroncek David, Palmieri Giuseppe, Chouchane Lotfi, Wang Ena, Marincola Francesco M

Abstract excerpt

BACKGROUND: The existence of a dichotomy between immunologically active and quiescent tumor phenotypes has been recently recognized in several types of cancer. The activation of a Th1 type of immune signature has been shown to confer better prognosis and likelihood to respond to immunotherapy. However, whether such dichotomy depends on the genetic make-up of individual cancers is not known yet. BRAF and NRAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25174651
DOI: 10.1016/j.molonc.2014.07.014
PMCID: PMC4500792

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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