Article
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment cell research - 1 Jun 2007
Johansson Peter, Pavey Sandra, Hayward Nicholas
Abstract excerpt
Mutations in the BRAF oncogene occur in the majority of melanomas, leading to the activation of the mitogen-activated protein kinase pathway and the transcription of downstream effectors. As BRAF and its effectors could be good melanoma therapy targets, defining the repertoire of genes that are d...
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