Article
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene - 20 May 2004
Pavey Sandra, Johansson Peter, Packer Leisl, Taylor Jennifer, Stark Mitchell, Pollock Pamela M, Walker Graeme J, Boyle Glen M, Harper Ursula, Cozzi Sarah-Jane, Hansen Katherine, Yudt Laura, Schmidt Chris, Hersey Peter, Ellem Kay A O, O'Rourke Michael G E, Parsons Peter G, Meltzer Paul, Ringnér Markus, Hayward Nicholas K
Abstract excerpt
We have used microarray gene expression profiling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines. The BRAF gene was found to be mutated in 42 samples (69%) and intragenic mutations of the NRAS gene were detected in seven samples (11%). No cell line carried mutations of both genes. Using support vector machines, we have built a classifier that differentiates...
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