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Article

Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation.

Journal for immunotherapy of cancer - 1 Apr 2022

Wang Minyu, Zadeh Soroor, Pizzolla Angela, Thia Kevin, Gyorki David E, McArthur Grant A, Scolyer Richard A, Long Georgina, Wilmott James S, Andrews Miles C, Au-Yeung George, Weppler Ali, Sandhu Shahneen, Trapani Joseph A, Davis Melissa J, Neeson Paul Joseph

Abstract excerpt

BACKGROUND: Patients with BRAF-mutant and wild-type melanoma have different response rates to immune checkpoint blockade therapy. However, the reasons for this remain unknown. To address this issue, we investigated the precise immune composition resulting from BRAF mutation in treatment-naive melanoma to determine whether this may be a driver for different response to immunotherapy. METHODS: In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35383113
DOI: 10.1136/jitc-2021-004095
PMCID: PMC8984014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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