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Article

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.

Neurobiology of aging - 1 Jan 2015

Lee Jang-Won, Tapias Victor, Di Maio Roberto, Greenamyre J Timothy, Cannon Jason R

Abstract excerpt

Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD. Enhanced kinase activity of G2019S LRRK2 is a suspected mechanism for carriers to develop PD but pathophysiological function of G2019S LRRK2 is not clear. The objective of the present study was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Nitric Oxide Synthase Type II

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Source

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Identifiers

PMID: 25174649
DOI: 10.1016/j.neurobiolaging.2014.07.011
PMCID: PMC5289148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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