Article
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease.
Atherosclerosis - 1 Nov 2014
Holmes Michael V, Frikke-Schmidt Ruth, Melis Daniela, Luben Robert, Asselbergs Folkert W, Boer Jolanda M A, Cooper Jackie, Palmen Jutta, Horvat Pia, Engmann Jorgen, Li Ka-Wah, Onland-Moret N Charlotte, Hofker Marten H, Kumari Meena, Keating Brendan J, Hubacek Jaroslav A, Adamkova Vera, Kubinova Ruzena, Bobak Martin, Khaw Kay-Tee, Nordestgaard Børge G, Wareham Nick, Humphries Steve E, Langenberg Claudia, Tybjaerg-Hansen Anne, Talmud Philippa J
Abstract excerpt
BACKGROUND: Conflicting evidence exists on whether smoking acts as an effect modifier of the association between APOE genotype and risk of coronary heart disease (CHD). METHODS AND RESULTS: We searched PubMed and EMBASE to June 11, 2013 for published studies reporting APOE genotype, smoking status and CHD events and added unpublished data from population cohorts. We tested for presence of effect modification by...
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