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Article

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.

Experimental biology and medicine (Maywood, N.J.) - 1 Apr 2016

Ward Christina M, Li Biaoru, Pace Betty S

Abstract excerpt

Sickle cell anemia is a common genetic disorder caused by a point mutation in the sixth codon of the β-globin gene affecting people of African descent worldwide. A wide variety of clinical phenotypes ranging from mild to severe symptoms and complications occur due to hemoglobin S polymerization, red blood cell sickling, and vaso-occlusion. Research efforts are ongoing to develop strategies of fetal hemoglobin...

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Source

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Identifiers

PMID: 26940952
DOI: 10.1177/1535370216636725
PMCID: PMC4950382

Genes

STAT3
KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.PMID 26940952Read ↗

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Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sicklingSemantic proximity Read ↗

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