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Article

Protein surface softness is the origin of enzyme cold-adaptation of trypsin.

PLoS computational biology - 1 Aug 2014

Isaksen Geir Villy, Åqvist Johan, Brandsdal Bjørn Olav

Abstract excerpt

Life has effectively colonized most of our planet and extremophilic organisms require specialized enzymes to survive under harsh conditions. Cold-loving organisms (psychrophiles) express heat-labile enzymes that possess a high specific activity and catalytic efficiency at low temperatures. A remarkable universal characteristic of cold-active enzymes is that they show a reduction both in activation enthalpy and...

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Identifiers

PMID: 25165981
DOI: 10.1371/journal.pcbi.1003813
PMCID: PMC4148182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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