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Article

Electrostatic effects play a central role in cold adaptation of trypsin.

FEBS letters - 15 Jun 2001

Brandsdal B O, Smalås A O, Aqvist J

Abstract excerpt

Organisms that live in constantly cold environments have to adapt their metabolism to low temperatures, but mechanisms of enzymatic adaptation to cold environments are not fully understood. Cold active trypsin catalyses reactions more efficiently and binds ligands more strongly in comparison to warm active trypsin. We have addressed this issue by means of comparative free energy calculations studying the binding...

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PMID: 11418134
DOI: 10.1016/s0014-5793(01)02552-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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