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Article

Towards Rational Computational Engineering of Psychrophilic Enzymes.

Scientific reports - 16 Dec 2019

Sočan Jaka, Isaksen Geir Villy, Brandsdal Bjørn Olav, Åqvist Johan

Abstract excerpt

Cold-adapted enzymes from psychrophilic species achieve their high catalytic efficiency at low temperature by a different partitioning of the activation free energy into its enthalpic and entropic components, compared to orthologous mesophilic enzymes. Their lower activation enthalpy, partly compensated by an increased entropic penalty, has been suggested to originate from changes in flexibility of the protein...

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Identifiers

PMID: 31844096
DOI: 10.1038/s41598-019-55697-4
PMCID: PMC6915740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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