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Article

The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response

21 Mar 2020

Abstract excerpt

Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the clinical success, not all patients respond to treatment or they develop resistance. Although there are several treatment predictive biomarkers, understanding therapy resistance and the mechanisms of tumor immune evasion is crucial to increase the frequency of...

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PMID: 32245160
DOI: 10.3390/cancers12030742

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