Article
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
The Journal of investigative dermatology - 1 Jan 2006
Goel Vikas K, Lazar Alexander J F, Warneke Carla L, Redston Mark S, Haluska Frank G
Abstract excerpt
Frequent somatic mutation of v-raf murine sarcoma viral oncogene homolog B (BRAF), a downstream effector of the rat sarcoma oncogene (RAS) signaling pathway, is described in melanoma and other tumors. Our analysis of melanoma cell lines suggests that activating mutations in BRAF can occur simultaneously with inactivation of phosphatase and tensin homolog (PTEN), but neuroblastoma RAS (NRAS) mutations are not...
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