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Article

Revisiting the Clinical and Biologic Relevance of Partial PTEN Loss in Melanoma.

The Journal of investigative dermatology - 1 Feb 2019

Giles Keith M, Rosenbaum Brooke E, Berger Marlies, Izsak Allison, Li Yang, Illa Bochaca Irineu, Vega-Saenz de Miera Eleazar, Wang Jinhua, Darvishian Farbod, Zhong Hua, Osman Iman

Abstract excerpt

The extent of PTEN loss that confers clinical and biological impact in melanoma is unclear. We evaluated the clinical and biologic relevance of PTEN dosage in melanoma and tested the postulate that partial PTEN loss is due to epigenetic mechanisms. PTEN expression was assessed by immunohistochemistry in a stage III melanoma cohort (n = 190) with prospective follow up. Overall, 21 of 190 (11%) tumors had strong...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30148988
DOI: 10.1016/j.jid.2018.07.031
PMCID: PMC6342667

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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