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Article

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.

The Journal of biological chemistry - 17 Oct 2014

Lawrence Scott A, Titus Steven A, Ferguson Jennifer, Heineman Amy L, Taylor Shirley M, Moran Richard G

Abstract excerpt

Folylpoly-γ-glutamate synthetase (FPGS) catalyze the addition of multiple glutamates to tetrahydrofolate derivatives. Two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria in mouse and human tissues. We sought to clarify the functions of these two compartmentalized isoforms. Stable cell lines were created that express cDNAs for the mitochondrial and cytosolic isoforms of human...

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Identifiers

PMID: 25164808
DOI: 10.1074/jbc.M114.593244
PMCID: PMC4200287

Genes

FPGS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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