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Article

Identification and characterization of genetic variation in the folylpolyglutamate synthase gene.

Cancer research - 15 Sept 2007

Leil Tarek A, Endo Chiaki, Adjei Araba A, Dy Grace K, Salavaggione Oreste E, Reid Joel R, Ames Matthew M, Adjei Alex A

Abstract excerpt

Folylpolyglutamate synthase (FPGS) catalyzes the polyglutamation of folic acid, methotrexate, and pemetrexed to produce highly active metabolites. To characterize genetic variation in the FPGS gene, FPGS, have resequenced the gene in four different ethnic populations. Thirty-four single nucleotid...

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Source

Identifiers

PMID: 17875718
DOI: 10.1158/0008-5472.CAN-07-0156

Genes

FPGS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17875718-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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