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Article

Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

Yang Chen, Xie Lin-Ying, Windle Jolene J, Taylor Shirley M, Moran Richard G

Abstract excerpt

The mouse is extensively used to model human folate metabolism and therapeutic outcomes with antifolates. However, the folylpoly-γ-glutamate synthetase (fpgs) gene, whose product determines folate/antifolate intracellular retention and antifolate antitumor activity, displays a pronounced species difference. The human gene uses only a single promoter, whereas the mouse uses two: P2, akin to the human promoter, at...

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Identifiers

PMID: 24532667
DOI: 10.1096/fj.13-243261
PMCID: PMC3986845

Genes

FPGS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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