Article
Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development.
The Plant journal : for cell and molecular biology - 1 Oct 2010
Mehrshahi Payam, Gonzalez-Jorge Sabrina, Akhtar Tariq A, Ward Jane L, Santoyo-Castelazo Anahi, Marcus Susan E, Lara-Núñez Aurora, Ravanel Stéphane, Hawkins Nathaniel D, Beale Michael H, Barrett David A, Knox J Paul, Gregory Jesse F, Hanson Andrew D, Bennett Malcolm J, Dellapenna Dean
Abstract excerpt
Cellular folates function as co-enzymes in one-carbon metabolism and are predominantly decorated with a polyglutamate tail that enhances co-enzyme affinity, subcellular compartmentation and stability. Polyglutamylation is catalysed by folylpolyglutamate synthetases (FPGSs) that are specified by t...
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