Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Molecular biology of the cell - 1 Mar 2014

Arndt Lilli, Castonguay Jan, Arlt Elisabeth, Meyer Dorke, Hassan Sami, Borth Heike, Zierler Susanna, Wennemuth Gunther, Breit Andreas, Biel Martin, Wahl-Schott Christian, Gudermann Thomas, Klugbauer Norbert, Boekhoff Ingrid

Abstract excerpt

The functional relationship between the formation of hundreds of fusion pores during the acrosome reaction in spermatozoa and the mobilization of calcium from the acrosome has been determined only partially. Hence, the second messenger NAADP, promoting efflux of calcium from lysosome-like compartments and one of its potential molecular targets, the two-pore channel 1 (TPC1), were analyzed for its involvement in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcimycin
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels

Share to Fertility

Share to Piperazines

Share to Reproduction

Share to Sperm Count

Source

Open in PubMed Open full text

Identifiers

PMID: 24451262
DOI: 10.1091/mbc.E13-09-0523
PMCID: PMC3952862

Genes

TPCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.PMID 24451262Read ↗

A Perspective on the Control of Mammalian Fertilization by Egg-Activated Ion Channels in Sperm: A Tale of Two Channels1Semantic proximity Read ↗

Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosisSemantic proximity Read ↗

Lipid Modulation of Calcium Flux through CaV2.3 Regulates Acrosome Exocytosis and FertilizationSemantic proximity Read ↗

Regulating the acrosome reactionSemantic proximity Read ↗

CatSper: The complex main gate of calcium entry in mammalian spermatozoaSemantic proximity Read ↗

Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction1Semantic proximity Read ↗

Lipid remodeling in acrosome exocytosis: unraveling key players in the human spermSemantic proximity Read ↗

Unresolved Questions Concerning Mammalian Sperm Acrosomal Exocytosis1Semantic proximity Read ↗

Cysteine-Rich Secretory Proteins (CRISP) are Key Players in Mammalian Fertilization and FertilitySemantic proximity Read ↗

Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reactionSemantic proximity Read ↗

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.Semantic proximity Read ↗

Ca<sup>2+</sup>Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome ReactionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.