Article
Rab3A and calmodulin regulate acrosomal exocytosis by mechanisms that do not require a direct interaction.
FEBS letters - 14 Aug 2002
Yunes R, Tomes C, Michaut M, De Blas G, Rodriguez F, Regazzi R, Mayorga L S
Abstract excerpt
The interaction between Rab3A and calmodulin is necessary for the inhibitory effect of Rab3A in neuroendocrine cells. Contrastingly, Rab3A triggers the exocytosis known as acrosome reaction in permeabilized spermatozoa. Here we show that a Rab3A mutant that cannot bind calmodulin was fully capable of triggering acrosomal exocytosis. Additionally, calmodulin by itself abrogated the exocytosis triggered by Rab3A....
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