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Article

EGFR mutation specific immunohistochemistry is a useful adjunct which helps to identify false negative mutation testing in lung cancer.

Pathology - 1 Oct 2014

Houang Michelle, Sioson Loretta, Clarkson Adele, Watson Nicole, Farzin Mahtab, Toon Christopher W, Raut Aditi, O'Toole Sandra A, Cooper Wendy A, Pavlakis Nick, Mead Scott, Chou Angela, Gill Anthony J

Abstract excerpt

Mutations in EGFR guide treatment in non-small cell lung cancer (NSCLC). The most common mutations, exon 19 (delE746-A750) and exon 21 (L858R), can be identified by mutation specific immunohistochemistry (IHC). We present our prospective experience of universal reflex IHC and molecular testing in non-squamous NSCLC in the routine clinical setting.A total of 411 specimens from 332 patients were encountered over...

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Identifiers

PMID: 25158821
DOI: 10.1097/PAT.0000000000000141

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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